Los Santos Vacations & Trips from $581

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Your Los Santos Vacation

Embark on a journey full of discovery and excitement with a vacation package to Los Santos. Known for its festivals and so much more, this destination will surprise and delight at every step. A trip to Los Santos wouldn't be complete without spending some time in its best cities, starting with Pedasi. Some of the top attractions here include Iguana Island National Park and Playa El Arenal. Las Tablas is another favorite with Los Santos travelers. Visitors to this exciting city enjoy El Uverito Beach and Playa Las Comadres. Expedia has everything you need for organizing your Los Santos vacation. From flights and accommodations, to rental cars and activities, we're here to help you curate a travel experience like no other.

Top destinations in Los Santos

View at Venao beach in Azuero peninsula, Panama.
FlightsFlightsHotelsHotels

Las Escobas del Venado

Las Escobas del Venado

The Latest Los Santos Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,080, price is now $581 per person
$581
per person
May 27 - Jun 1
found 19 hours ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
Gréât location and the staff at the gate. Rom had everything except extra towells and cleaning liquids. Love to come again to stay in this property!

Reviewed on Mar 8, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,655, price is now $1,042 per person
$1,042
per person
Apr 30 - May 7
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
8.4/10 Very Good! (1,441 reviews)
The room are nice and clean the pool is too much noise. It’s a mess

Reviewed on Mar 10, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,278, price is now $876 per person
$876
per person
May 22 - May 29
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (5,057 reviews)
The hotel was marketed as a 5-star property, but it didn’t quite live up to that standard. The restaurants and buffet were pretty underwhelming, and the hotel overall felt a bit dated. The pool area was decent, but the staff there were noticeably rude, which hurt the experience. That said, there were some positives. The front desk staff were friendly, the housekeeping team did a great job, and everything throughout the hotel was very clean. The room itself was well laid out and comfortable, and the bed was great for our 8-night stay. Overall, it’s a clean and comfortable hotel, but it doesn’t feel like a true 5-star experience.

Reviewed on Mar 10, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $2,122, price is now $1,455 per person
$1,455
per person
May 15 - May 22
found 23 hours ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9/10 Wonderful! (1,010 reviews)
Great location clean safe and walkable!! Wonderful hotel

Reviewed on Mar 10, 2026

Yoo by Wynwood House

Yoo by Wynwood House

4 out of 5
Calidonia
Price was $1,834, price is now $1,264 per person
$1,264
per person
Apr 27 - May 4
found 1 day ago
Roundtrip flight included
Bridgetown (BGI) to Panama City (PTY)
9.2/10 Wonderful! (5 reviews)
Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025

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Best Places to Vacation in Los Santos

1. Find your perfect Las Escobas del Venado vacation

Las Escobas del Venado in Los Santos, Panama offers the perfect atmosphere for a beach vacation. With its secluded and pristine beaches, it is an ideal destination for those looking to relax and enjoy nature. The area is also known for its great surfing opportunities, with waves that cater to both beginners and experienced surfers. Visitors can take long walks along the shoreline, bask in the warm sun, and admire breathtaking sunsets. For those seeking a lively atmosphere, there are beach bars where you can sip on refreshing drinks and soak in the vibrant marina scene.

  • Travelers tend to stay 3 days in Las Escobas del Venado

2. Escape to Pedasi with a vacation package

Pedasi in Los Santos, Panama, offers a perfect atmosphere for a beach vacation. With its stunning geographic location and beautiful beaches, it is an ideal destination for relaxation. The locals in Pedasi are known for their friendliness and welcoming nature, making visitors feel right at home. The town also offers a variety of dining options, allowing travelers to indulge in delicious local cuisine. Some popular activities for travelers to enjoy here are vacation packages that include beach activities and exploring the natural beauty of the area. Overall, Pedasi promises a memorable and enjoyable beach vacation experience.

  • The peak season is from January to March
  • The off-peak season is from August to October
  • Travelers tend to stay 3 days in Pedasi

3. Discover Las Tablas with our vacation deals

Las Tablas, located in Los Santos, Panama, is the perfect destination for a beach vacation. With its budget-friendly options and abundance of excursions, visitors can enjoy the stunning sandy beaches and crystal-clear waters. Seafood lovers will delight in the fresh and delicious seafood options available, while adventure enthusiasts can partake in activities like walking and exploring the natural parks. Las Tablas is also a family-friendly destination, offering a range of activities suitable for all ages. Whether you're looking for relaxation or adventure, Las Tablas has it all.

  • The peak season is from December to February
  • The off-peak season is from April to June
  • Travelers tend to stay 2 days in Las Tablas

4. Enjoy Cambutal with a travel package

Cambutal, located in Los Santos, Panama, offers a serene and picturesque beach vacation experience. Nestled within stunning geographic affinities, this coastal destination is perfect for relaxation and rejuvenation. With its pristine sandy beaches and crystal-clear turquoise waters, Cambutal is ideal for sunbathing, swimming, and water sports. The local atmosphere is laid-back and welcoming, allowing travelers to unwind and immerse themselves in the natural beauty of the surroundings. Whether you choose to explore the lush rainforests nearby or simply bask in the sun, Cambutal provides an idyllic beach getaway for travelers seeking tranquility and natural splendor.

  • Travelers tend to stay 4 days in Cambutal

6. Plan your dream getaway to Guanico Abajo

Guanico Abajo in Los Santos, Panama, offers a delightful beach vacation experience. With its beautiful coastline and picturesque surroundings, it is the perfect destination for relaxation and fun in the sun. The local atmosphere is laid-back and friendly, allowing travelers to immerse themselves in the tranquil vibes of this coastal town. Whether you want to lounge on the sandy beaches, go swimming in the crystal-clear waters, or explore the nearby nature reserves, Guanico Abajo has something for everyone. Experience the beauty and charm of this beach paradise during your vacation stay.

  • Travelers tend to stay 3 days in Guanico Abajo

5. Explore Canas with a vacation package

Canas, located in the beautiful region of Los Santos, Panama, offers an idyllic beach vacation experience. With its pristine white sand beaches and crystal-clear turquoise waters, it's the perfect destination for relaxation and rejuvenation. The local atmosphere is laid-back and welcoming, with friendly locals and a peaceful ambiance. Whether you want to soak up the sun, enjoy water activities like snorkeling and swimming, or simply unwind with a book by the shore, Canas has it all. Immerse yourself in the local culture, indulge in delicious seafood, and savor breathtaking sunsets over the Pacific Ocean for an unforgettable beach vacation.

  • Travelers tend to stay 2 days in Canas

Find the Best Los Santos Vacation Packages

Los Santos Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)
Top Sights
Venao Beach, El Uverito Beach and Playa El Toro

Los Santos Hotel Deals

Villa Marina Hotel

Villa Marina Hotel

3.5 out of 5
Playa Venao Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
$185 nightly
The price is $207 total per night from Mar 29 to Mar 30
$207 total
Mar 29 - Mar 30
Total with taxes and fees
Villa Marina Hotel
Selina Playa Venao - Hostel

Selina Playa Venao - Hostel

3 out of 5
Playa Venao 1 Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $107 total per night from Mar 11 to Mar 12
$107 total
Mar 11 - Mar 12
Total with taxes and fees
7.8/10 Good! (103 reviews)
I didn't get a wink of sleep.The bar played extremely loud music that filtered throughout until 4 am. Kind of like the sleep deprivation torture at Guantanamo!

Reviewed on Jan 27, 2026

Selina Playa Venao - Hostel
Hotel Punta Franca

Hotel Punta Franca

3 out of 5
Camino a Puerto Escondido Punta Mala Los Santos
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Mar 12 to Mar 13
$75 total
Mar 12 - Mar 13
Total with taxes and fees
8.8/10 Excellent! (168 reviews)
The place is very well located with an incredible ocean view, however, it’s not well maintained. I staid there 2 nights and I could not use any of the pools as they were dirty. You could see the filth resting at the bottom. Also, the mattress was old and it had a very noticeable indentation that ...

Reviewed on Feb 22, 2026

Hotel Punta Franca
See all 386 properties in Los Santos
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Los Santos vacation package cost?
Our Los Santos packages, which begin from just $581, are an awesome way to save precious money. Select your favorite hotels, flights and more to create your ideal trip.
How do I get a cheap travel package to Los Santos?
Combine your hotel and flight bookings, throw in extras such as activities or a rental car, and save with a Los Santos vacation package. You won't just land big discounts on your adventure — you'll have a world of choice within your reach too. When you book with Expedia, you can choose from more than 550 air carriers and 1,000,000 properties globally. Your next big adventure starts right here, right now!
What are the top hotels in Los Santos?
For properties in Las Escobas del Venado with cozy beds and friendly service, you can't beat Hotel Presidente and Villa Marina Lodge And Condos. If you're swinging by Pedasi as well, you'll get a good night's sleep at Hotel Punta Franca or Selina Playa Venao - Hostel.
How far in advance should I book my Los Santos vacation?
While prices change frequently, we generally recommend reserving your seat as soon as possible. Most international airfares can be compared on Expedia up to a year in advance. If circumstances have left you booking last minute, you might still get lucky. Cheap tickets to Los Santos sometimes appear only weeks before departure.
What does an Expedia Los Santos travel package include?
Flights, hotels and a reliable car for all your fun road trip adventures. Simply select your preferred bundle and get access to great discounts. Once you've made your booking, add on some experiences and tours and watch your savings pile up. When it comes to planning your Los Santos trip, you're the boss!
What should I know before booking a Los Santos travel package?
When you book your hotels, flights and car rentals together, you'll pick up awesome discounts. Whether you're planning an island getaway in a villa or would rather stay in a fancy hotel in the city, Expedia can help make it happen.
Can I choose my airline with a Los Santos Expedia vacation package?
With a vacation package, you're the one in charge. Whether you'd like to fly to Los Santos in first class or coach, simply select from the available airline options. Expedia has access to over 550 airline partners around the world.
Does Expedia offer Book Now, Pay Later Los Santos vacation packages?
Thanks to our partnership with online lender Affirm, vacationers booking via Expedia can now pay off their journey in easy installments that won't hurt your savings. Book Now, Pay Later and begin your dream vacation today!
If I'm not able to travel, can I cancel my Los Santos vacation package?
Your situation can change suddenly, so yes, you can. You may be able to amend or cancel your Los Santos vacation package at no cost within 24 hours of booking. For bookings made more than 24 hours ago, you can still cancel or make changes, but your car rental company, airline or hotel may impose a charge. Want more information? Look up our Customer Service Portal. We're here to help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Los Santos

Selina Hostels at Playa Venao The hostel is new and not finished yet, but it has a great design, is located directly at the beach and the staff is really cool. A con is that there is only one shop which has basically nothing and is really expensive; so you either have to bring your food or eat at the bar in the hostel. The beach itself is good for surfers, but you can also enjoy the waves without a board. There are only two (or maybe three; nobody knows) buses from Pedasí to Playa Venao: once in the morning (I think at 7) and once at 12 o'clock. It takes around 1.5 hours. Keep your eyes open and when you see the sign of the hostel, shout

Los Destiladeros Beach

If a restful vacation is part of your travel plans, Los Destiladeros Beach might be the perfect place to seek out during your trip to Punta Mala.

Los Destiladeros Beach
Sunset at Sansara

Los Buzos Beach

If a restful vacation is part of your travel plans, Los Buzos Beach might be the perfect place to seek out during your trip to Cambutal.

Los Buzos Beach
The birds at Playa El Arenal's rustic sandy beach, where boat rides to Isla Iguana Wildlife Refuge are commencing.

Playa El Arenal

If a restful vacation is part of your travel plans, Playa El Arenal might be the perfect place to seek out during your trip to Pedasí.

Playa El Arenal
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.